Postmarketing circumstances of respiratory depression, such as fatalities have been documented with use of promethazine in pediatric people.

Codeine is not advised to deal with cough or ache and tramadol just isn't advised to deal with ache in adolescents among 12 and eighteen several years who're obese or have circumstances such as obstructive slumber apnea or critical lung condition that could enhance the possibility of respiration issues.

Normally talk to your Health care company to be certain the data exhibited on this page applies to your personal circumstances.

Will not choose any benzodiazepines or medicines that might cause drowsiness or sleepiness for the duration of treatment with PROMETHAZINE VC WITH CODEINE ORAL Answer. Inquire your Health care company for a summary of these medicines if you are not sure.

No evidence of tumorigenicity was observed in male and feminine mice at codeine dietary doses as much as 400 mg/kg/working day (around akin to 44 instances the MRHD on the mg/m 2 foundation). Codeine was not mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic inside the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.

If Promethazine with Codeine Oral Solution is employed for a prolonged time period in a very pregnant woman, suggest the affected individual of the risk of neonatal opioid withdrawal syndrome and be sure that ideal therapy is going to be out there [see Warnings and Precautions (5.20)].

The concomitant use of anticholinergic medications with Promethazine with Codeine Oral Remedy could enhance danger of urinary retention and/or extreme constipation, which may bring about paralytic ileus [seeWARNINGS AND Safeguards (5.

The dosage of Promethazine with Codeine Oral Resolution really should not be greater if cough fails to respond; an unresponsive cough really should be reevaluated for doable fundamental pathology.

Suitable evaluation in the affected individual, appropriate prescribing techniques, periodic re-evaluation of therapy, and proper dispensing and storage are acceptable steps that assist to limit abuse of opioid prescription drugs.

Hemodialysis just isn't routinely used to improve the elimination of codeine or promethazine from the body.

This item may possibly include inactive elements, which could result in allergic reactions or other complications. Talk with your pharmacist for more information.

This is simply not a complete listing of achievable Uncomfortable side effects. In case you discover more info other side effects not stated over, Call your medical professional or pharmacist.

The concomitant use of opioids with other prescription drugs that have an impact on the serotonergic neurotransmitter program has resulted in serotonin syndrome.

The causal function of opioids from the clinical syndrome of hypogonadism is mysterious as the different medical, Bodily, Life-style, and psychological stressors that may influence gonadal hormone degrees haven't been adequately controlled for in experiments performed so far [ see Adverse Reactions ( six) ]. Effects within the Immune Procedure Opioids happen to be proven to acquire a variety of results on elements with the immune system in in vitro and animal designs. The medical significance of those results is mysterious. In general, the consequences of opioids appear to be modestly immunosuppressive.